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The Journal of Respiratory Diseases. Vol. 29 No. 12
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DIAGNOSTIC PUZZLERS
Challenging cases to test your clinical skills 

A patient with cough and progressive dyspnea

By LISA CHEN, DO, NICK PATEL, DO, and ARUNABH TALWAR, MD
SECTION EDITOR: ARUNABH TALWAR, MD

| December 2, 2008

Dr Chen is an internal medicine resident and Dr Patel is a pulmonary and critical care medicine fellow at North Shore–Long Island Jewish Health System, New Hyde Park, New York. Dr Talwar is associate professor of medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, and an attending physician, division of pulmonary, critical care, and sleep medicine at North Shore–Long Island Jewish Health System.


A 47-year-old man with HIV infection presented with progressive dyspnea and worsening productive cough for the past 3 weeks. He also reported increasingly purulent sputum production. The patient reported being adherent to his antiretroviral regimen, and he had an admission CD4+ cell count of 550/μL. He did not have any previous opportunistic infections, and he denied any drug or tobacco use, recent travel, and ill contacts.

Findings from the physical examination were unremarkable with stable vital signs. Lung sounds were clear bilaterally, but the patient was producing purulent sputum.

Laboratory values revealed a leukocytosis with a white blood cell count of 17,000/μL and a neutrophil predominance. Other laboratory findings, including toxicology screening results, were normal. A CT scan of the chest was obtained (Figure 1). The patient subsequently underwent bronchoscopy (Figure 2).

Figure 1

 

Figure 2

 

What is the likely diagnosis?  

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